False memories prime immune system for future attacks

IN A police line-up, a falsely remembered face is a big problem. But for the body's police force – the immune system – false memories could be a crucial weapon.

When a new bacterium or virus invades the body, the immune system mounts an attack by sending in white blood cells called T-cells that are tailored to the molecular structure of that invader. Defeating the infection can take several weeks. However, once victorious, some T-cells stick around, turning into memory cells that remember the invader, reducing the time taken to kill it the next time it turns up.

Conventional thinking has it that memory cells for a particular microbe only form in response to an infection. "The dogma is that you need to be exposed," says Mark Davis of Stanford University in California, but now he and his colleagues have shown that this is not always the case.

The team took 26 samples from the Stanford Blood Center. All 26 people had been screened for diseases and had never been infected with HIV, herpes simplex virus or cytomegalovirus. Despite this, Davis's team found that all the samples contained T-cells tailored to these viruses, and an average of 50 per cent of these cells were memory cells.

The idea that T-cells don't need to be exposed to the pathogen "is paradigm shifting," says Philip Ashton-Rickardt of Imperial College London, who was not involved in the study. "Not only do they have capacity to remember, they seem to have seen a virus when they haven't."

So how are these false memories created? To a T-cell, each virus is "just a collection of peptides", says Davis. And so different microbes could have structures that are similar enough to confuse the T-cells.

To test this idea, the researchers vaccinated two people with an H1N1 strain of influenza and found that this also stimulated the T-cells to react to two bacteria with a similar peptide structure. Exposing the samples from the blood bank to peptide sequences from certain gut and soil bacteria and a species of ocean algae resulted in an immune response to HIV (Immunology, doi.org/kgg).

The finding could explain why vaccinating children against measles seems to improve mortality rates from other diseases. It also raises the possibility of creating a database of cross-reactive microbes to find new vaccination strategies. "We need to start exploring case by case," says Davis.

"You could find innocuous pathogens that are good at vaccinating against nasty ones," says Ashton-Rickardt. The idea of cross-reactivity is as old as immunology, he says. But he is excited about the potential for finding unexpected correlations. "Who could have predicted that HIV was related to an ocean algae?" he says. "No one's going to make that up!"

This article appeared in print under the headline "False memories prime our defences"

If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.

All comments should respect the New Scientist House Rules. If you think a particular comment breaks these rules then please use the "Report" link in that comment to report it to us.

If you are having a technical problem posting a comment, please contact technical support.

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"Argo", "Lincoln" vie for Oscars crown in open race

LOS ANGELES - Steven Spielberg goes into next weekend's Oscars with the most nominations for his presidential "Lincoln" but the momentum is all with Ben Affleck's thriller "Argo" in the Academy Awards home straight.

And while the Hollywood veteran and the young pretender vie for the Oscars best picture crown, several other frontrunners remain hard on their heels, in one of the least predictable Oscar races in recent memory.

Taiwan-born Lee Ang's 3D spectacular "Life of Pi," Osama bin Laden manhunt movie "Zero Dark Thirty" and romcom "Silver Linings Playbook" could all be in with a chance at the Oscars, the climax of Tinseltown's annual awards season.

Spielberg and Lee are frontrunners for best director, while "Lincoln" star Daniel Day-Lewis is widely seen as a shoo-in for best actor. For best actress the hot money is on Jessica Chastain for her part in "Zero Dark Thirty" or "Hunger Games" star Jennifer Lawrence.

But Affleck's Iran hostage drama, despite only winning seven nominations -- against 12 for "Lincoln," 11 for "Life of Pi" and eight each for "Silver Linings Playbook" and "Les Miserables" -- has a clear edge for best picture.

It has swept up top prizes at a string of key awards shows, including the Golden Globes, the Screen Actors Guild (SAG), Producers Guild of America (PGA), the Directors Guild of America (DGA), and Britain's BAFTA last weekend.

Affleck has gotten used to making acceptance speeches over the last two months -- but he has been tightlipped on his prospects for the all-important 85th Academy Awards, to be held at Hollywood's Dolby Theatre next Sunday.

"I just feel so incredibly honoured to be nominated as a producer for this movie. To be here at the big party," he said at the Oscar Nominees Luncheon, the annual gathering of those in the race, held in Beverly Hills on February 4.

Indeed, his best picture nomination is as a co-producer of the film -- along with George Clooney and Grant Heslov -- rather than as a director, a category in which he was not nominated, in a perceived snub.

Snub or no snub, he will be among presenters at the show, along with a Who's Who of A-listers including Halle Berry, Sandra Bullock, Nicole Kidman, Reese Witherspoon, Robert Downey Jr, Samuel L Jackson, and Meryl Streep.

"Family Guy" creator Seth MacFarlane will be hosting, a move organizers hope will attract younger viewers among the hundreds of millions watching live around the world.

Other nominees presenting include Chastain -- best actress frontrunner for playing a relentless CIA agent on the hunt for Osama, in Oscar-winning director Kathryn Bigelow's controversial "Zero Dark Thirty".

But Lawrence, star of the "Hunger Games" blockbuster franchise, could also win the category for her portrayal of mixed-up Tiffany to Bradley Cooper's bipolar ex-teacher in "Silver Linings Playbook".

Cooper is up for best actor, along with Hugh Jackman for "Les Miserables", Joaquin Phoenix for "The Master" and Denzel Washington for "Flight" -- but Day-Lewis is widely forecast for a record third Oscar for his "Lincoln" turn.

For best director, 66-year-old Spielberg will be hoping for his first Oscar since "Saving Private Ryan" in 1999.

But he is up against Lee -- whose "Brokeback Mountain" won best picture in 2006 -- as well as Michael Haneke for his Cannes-winning "Amour", David O Russell for "Silver Linings Playbook" and Benh Zeitlin for "Beasts of the Southern Wild".

Best supporting actor nominees are Alan Arkin for "Argo", Robert De Niro for "Silver Linings Playbook", Philip Seymour Hoffman for "The Master", Tommy Lee Jones for "Lincoln" and Christoph Waltz for "Django Unchained".

For supporting actress Anne Hathaway is tipped to win for performance in "Les Miserables" -- including her heart-wrenching close-up rendition of "I Dreamed a Dream" -- against Amy Adams for "The Master", Sally Field in "Lincoln", Helen Hunt in "The Sessions" and Jacki Weaver in "Silver Linings Playbook".

The Oscars have a musical theme this year, including a performance by Britain's Adele singing the Oscar-nominated 007 theme tune "Skyfall" as well as by Shirley Bassey and Norah Jones, and Barbra Streisand, in her first Oscars turn since 1977.

- AFP/ir

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Russian meteorite: The conspiracy theories

A strange time for a military attack?

(Credit:
CNN; screenshot by Chris Matyszczyk/CNET)

A good hearty conspiracy theory can shine a sharp light on two of humanity's most enduring traits.

One, of course, is humanity's boundless imagination. The other is humanity's essential suspicion of humanity.

So while you might be deeply immersed in Bill Nye's explanation of the Russian meteorite, those with darker sensibilities have filled the Web with their fears and hauntings about the phenomenon.

There are few nations with greater awareness of dark sensibilities than Russia. The fact that there seems to be little evidence of meteorite fragments on the ground has encouraged some Russians to offer their own suspicions.

As the Toronto Globe and Mail reports, nationalist leader Vladimir Zhirinovsky hasn't been slow to offer something of a Hot War perspective.

"It's not meteors falling. It's a new weapon being tested by the Americans," he was quoted as saying.

We know from our recent experience of North Korea that weapons testing is an imprecise science.

But if you were an American in the mood to test a weapon, would Chelyabinsk, Russia, be your very first choice of place for the experiment?

Perhaps Tallahassee; Area 51; and Bialystok, Poland, were all unavailable due to prior commitments. Or perhaps it wasn't the Americans, but, say, the North Koreans, who mistook Chelyabinsk for, say, Chelsea.

Zhirinovsky's rather emotionally manipulative offering was countered by Russia's Emergency Ministry, which dedicated itself to an extensive rebuttal of his belief (and that of others) that this was some sort of military thing. The rebuttal? "Rubbish."

But that wasn't going to put off the local media, was it? Not only do they have papers to sell, they also have theories to expound to a troubled nation and world.

So, as The Atlantic reports, the local Znak newspaper accepted that this was a meteorite but insisted the explosion was caused by military defense blowing it up.

More Technically Incorrect

Yes, of course it has a source in the military. You thought it didn't?

Though I've watched a few movies in which exciting things happen, I don't find it easy to imagine that some sort of terrestrially created missile-laden aircraft could really explode a meteorite in such a manner.

It is easier to imagine, though, that politicians like Zhirinovsky might take the opportunity to foment a little rage.

Indeed, Alex Jones' infamously well-guarded Infowars site offered that Zhirinovsky insisted that America -- in the person of Secretary of State John Kerry -- had tried to give Russia advance notice of its "attack."

The Drudge Report led me to a piece at Foreign Policy that explained that Sergey Lavrov, Russia's foreign minister, simply hadn't called Kerry back.

Which all suggests that Russia isn't, after all, living in fear of an attack from the U.S. Especially one over Chelyabinsk.

On balance, I prefer to currently believe Nye. He is the science guy, after all. And science guys know scientific events when they see them.

I hope.

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Picture Archive: Making Mount Rushmore, 1935-1941

Photograph from Rapid City Chamber of Commerce/National Geographic

There's no such thing as Presidents' Day.

According to United States federal government code, the holiday is named Washington's Birthday, and has been since it went nationwide in 1885.

But common practice is more inclusive. The holiday expanded to add in other U.S. presidents in the 1960s, and the moniker Presidents' Day became popular in the 1980s and stuck. It may be that George Washington (b. February 22, 1732) andAbraham Lincoln (b. February 12, 1809) still get the lion's share of attention—and appear in all the retail sale ads—on the third Monday in February, but the popular idea is that all 44 presidents get feted.

Mount Rushmore is a lot like that one day a year writ large—and in granite. It's carved 60 feet (18 meters) tall and 185 feet (56 meters) wide, from Washington's right ear to Lincoln's left.

The monument's sculptor, Gutzon Borglum, grew up in Idaho, a first-generation American born to Danish parents. He studied art in France and became good friends with Auguste Rodin. Borglum mostly worked in bronze, but in the early 1910s he was hired to carve the likenesses of Confederate leaders into Stone Mountain in Georgia.

He was about to be fired from that job for creative differences about the same time that a South Dakota historian named Doane Robinson had an idea. Robinson wanted to have a monument carved into the Black Hills of South Dakota, maybe Western historical figures like Chief Red Cloud and Lewis and Clark, each on their own granite spire. (Plan a road trip in the Black Hills.)

Robinson hired Borglum and gave him carte blanche. Borglum was looking for something with national appeal, so he chose to depict four presidents: George Washington, Thomas Jefferson, Theodore Roosevelt, and Abraham Lincoln.

Borglum wanted to represent the first 150 years of the nation's history, choosing four presidents as symbols of their respective time periods. He took a tour of western South Dakota, searching for an ideal canvas.

The sculptor was looking for three things: a surface strong enough to sculpt, a mountain big enough to hold several figures, and a mountain face that received morning sunlight. Mount Rushmore fit the bill and was already part of a national forest, so it was easy to set aside as a national memorial.

Work started in 1927. Calvin Coolidge attended the dedication ceremony. It took 14 years to finish the carving, conducted mostly in summertime because of the area's harsh winters.

There were approximately 30 workers on the mountain at any give time. In total about 400 had worked on it by the time the monument was finished. Though the project involved thousands of pounds of dynamite and perilous climbs, not a single person died during the work.

Borglum himself died of natural causes in 1941, though, just six months before the project was declared "closed as is" by Congress that Halloween. His son Lincoln—named for his father's favorite president—took over.

In the photo above, a worker refines the details of Washington's left nostril.

About 90 percent of the mountain was carved using dynamite, which could get within 3 to 5 inches (8 to 13 centimeters) of the final facial features. For those last few inches, workers used what was known as the honeycomb method: Jackhammer workers pounded a series of three-inch-deep holes followed up by chiselers who knocked off the honeycomb pieces to get the final shape. Then carvers smoothed the "skin's" surface.

—Johnna Rizzo

February 16, 2013

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Meteor Blast 'Something We Only Saw in Movies'

A day after a massive meteor exploded over this city in central Russia, a monumental cleanup effort is under way.

Authorities have deployed around 24,000 troops and emergencies responders to help in the effort.

Officials say more than a million square feet of windows -- the size of about 20 football fields -- were shattered by the shockwave from the meteor's blast. Around 4,000 buildings in the area were damaged.

The injury toll climbed steadily on Friday. Authorities said today it now stands at more than 1,200. Most of those injuries were from broken glass, and only a few hundred required hospitalization.

According to NASA, this was the biggest meteor to hit Earth in more than a century. Preliminary figures suggest it was 50 feet wide and weighed more than the Eiffel Tower.

SEE PHOTOS: Meteorite Crashes in Russia

NASA scientists have also estimated the force of the blast that occurred when the meteor fractured upon entering Earth's atmosphere was approximately 470 kilotons -- the equivalent of about 30 Hiroshima bombs.

Residents said today they still can't believe it happened here.

"It was something we only saw in the movies," one university student said. "We never thought we would see it ourselves."

Throughout the city, the streets are littered with broken glass. Local officials have announced an ambitious pledge to replace all the broken windows within a week. In the early morning hours, however, workers could still be heard drilling new windows into place.

Authorities have sent divers into a frozen lake outside the city, where a large chunk of the meteor is believed to have landed, creating a large hole in the ice. By the end of the day they had not found anything.

They are not the only ones looking for it.

Meteor hunters from around the world are salivating at what some are calling the opportunity of a lifetime. A small piece of the meteor could fetch thousands of dollars and larger chunks could bring in even hundreds of thousands.

Read More..

False memories prime immune system for future attacks

IN A police line-up, a falsely remembered face is a big problem. But for the body's police force – the immune system – false memories could be a crucial weapon.

When a new bacterium or virus invades the body, the immune system mounts an attack by sending in white blood cells called T-cells that are tailored to the molecular structure of that invader. Defeating the infection can take several weeks. However, once victorious, some T-cells stick around, turning into memory cells that remember the invader, reducing the time taken to kill it the next time it turns up.

Conventional thinking has it that memory cells for a particular microbe only form in response to an infection. "The dogma is that you need to be exposed," says Mark Davis of Stanford University in California, but now he and his colleagues have shown that this is not always the case.

The team took 26 samples from the Stanford Blood Center. All 26 people had been screened for diseases and had never been infected with HIV, herpes simplex virus or cytomegalovirus. Despite this, Davis's team found that all the samples contained T-cells tailored to these viruses, and an average of 50 per cent of these cells were memory cells.

The idea that T-cells don't need to be exposed to the pathogen "is paradigm shifting," says Philip Ashton-Rickardt of Imperial College London, who was not involved in the study. "Not only do they have capacity to remember, they seem to have seen a virus when they haven't."

So how are these false memories created? To a T-cell, each virus is "just a collection of peptides", says Davis. And so different microbes could have structures that are similar enough to confuse the T-cells.

To test this idea, the researchers vaccinated two people with an H1N1 strain of influenza and found that this also stimulated the T-cells to react to two bacteria with a similar peptide structure. Exposing the samples from the blood bank to peptide sequences from certain gut and soil bacteria and a species of ocean algae resulted in an immune response to HIV (Immunology, doi.org/kgg).

The finding could explain why vaccinating children against measles seems to improve mortality rates from other diseases. It also raises the possibility of creating a database of cross-reactive microbes to find new vaccination strategies. "We need to start exploring case by case," says Davis.

"You could find innocuous pathogens that are good at vaccinating against nasty ones," says Ashton-Rickardt. The idea of cross-reactivity is as old as immunology, he says. But he is excited about the potential for finding unexpected correlations. "Who could have predicted that HIV was related to an ocean algae?" he says. "No one's going to make that up!"

This article appeared in print under the headline "False memories prime our defences"

If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.

All comments should respect the New Scientist House Rules. If you think a particular comment breaks these rules then please use the "Report" link in that comment to report it to us.

If you are having a technical problem posting a comment, please contact technical support.

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Alleged cop killer died from single shot to head

LOS ANGELES: Alleged US cop killer Christopher Dorner died from a single gunshot wound to the head that appeared to be self-inflicted, a coroner said.

The doctor who examined the body concluded that "the cause of death was a single gunshot wound to the head," said San Bernardino County coroner Kevin Lacy, giving details from the results of a six-hour autopsy.

"We are not yet able to speak about the manner of death and tell you whether or not it was the result of a self-inflicted wound or another round," he told a press conference.

But he said, "while we are still assembling the reports and putting it together, the implication seems to be that the wound that took Christopher Dorner's life was self-inflicted."

The ex-Los Angeles Police Department (LAPD) cop went on the run last week after allegedly killing a couple and a policeman, and wounding three people. Another officer was killed and one wounded before the cabin in which Dorner was holed up burned in a fire.

Dorner had posted online a chilling manifesto in which he threatened to kill policemen and their families, and blamed the LAPD for treating him unfairly in his sacking in 2008.

The manhunt came to a climax Tuesday in a cabin near a snow-covered ski resort, after Dorner was spotted in a stolen vehicle and then fled on foot after crashing one vehicle and carjacking another.

San Bernardino County Sheriff John McMahon said that there was a prolonged firefight with the 33-year-old, who barricaded himself in the cabin after a six-day manhunt.

When they had exhausted other means, SWAT officers used a tractor-type device to open up the windows and walls of the cabin, and inserted a pyrotechnic chemical, to try to force Dorner to surrender.

A blaze erupted, starting at one corner of the cabin. As the flames took hold, after a period of no firing, "We heard a distinct single gunshot coming from inside the house," said McMahon.

The sound of it "indicated to me (that) a different kind of weapon had been fired," he added.

- AFP/ck

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Crave Ep. 109: The greatest drinking game ever

The greatest drinking game ever, Ep: 109

Subscribe to Crave:

iTunes (HD) | iTunes (SD) | iTunes (HQ)

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This week on Crave, William Shatner has some choice words for J.J. Abrams, and we toss one back in the greatest drinking game ever invented. Cheers! Plus, we dodge a bullet the size of a football field as an asteroid nearly collides with Earth. Phew.

Crave stories:

- Shatner: J.J. Abrams a 'pig' for taking on 'Star Wars'

- Another close asteroid encounter for Earth coming Friday

- Injury count rises for Russian meteorite

- Sonic Wallets scream, moo, hurl insults when opened

- $11 million sought to build X-wing, counter Kickstarter Death Star

- Beercade: Fighting-game winner gets a frosty brew

- Crave giveaway: Aperion Audio Verus Forte speakers

Social networking:

- Stephen on Twitter

- Stephen on Google+

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Severe Weather More Likely Thanks to Climate Change

Jane J. Lee

BOSTON—Wildfires. Droughts. Super storms.

As opposed to representing the unfortunate severe weather headlines of the last year, scientists said Friday that climate change has increased the likelihood of such events moving forward.

And though the misery is shared from one U.S. coast to another, scientists speaking at the annual American Association for the Advancement of Science meeting in Boston said, the type of extreme event may vary significantly from region to region. (Related: "6 Ways Climate Change Will Affect You.")

Heat waves have become more frequent across the United States, with western regions setting records for the number of such events in the 2000s, said Donald Wuebbles, a geoscientist with the University of Illinois at Urbana-Champaign.

But the Midwest and Northeast have experienced a 45 percent and 74 percent increase, respectively, in the heaviest rainfalls those regions have seen since 1950.

The extreme drought that plagued Texas in 2011 has spread to New Mexico, Louisiana, Oklahoma, and northern Mexico, said John Nielsen-Gammon, Texas State's climatologist at Texas A&M University in College Station.

"The science is clear and convincing that climate change is happening and it's happening rapidly. There's no debate within the science community ... about the changes occurring in the Earth's climate and the fact that these changes are occurring in response to human activities," said Wuebbles.

In 2011 and 2012, major droughts, heat waves, severe storms, tornadoes, floods, hurricanes, and wildfires caused about $60 billion in damages each year, for a total of about $120 billion.

According to the National Oceanic and Atmospheric Administration Climactic Data Center, these were some of the costliest weather events in the country's history, said Wuebbles.

President Obama argued in his State of the Union address this week that the time is ripe to address climate change, saying he would skirt Congress to make such changes, if necessary.

His proposals included a system similar to the cap-and-trade proposal killed in Congress during his first term, new regulations for coal-burning power plants, and a promise to promote energy efficiency and R&D efforts into cleaner technologies. (Related: "Obama Pledges U.S. Action on Climate, With or Without Congress.")

The researchers said they are glad to see that addressing climate change is on the President's agenda. But they stressed that they wanted the public to have access to accurate, scientifically sound information, not just simplified talking points.

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Carnival Cruise Ship Hit With First Lawsuit

The first lawsuit against Carnival Cruise Lines has been filed and it is expected to be the beginning of a wave of lawsuits against the ship's owners.

Cassie Terry, 25, of Brazoria County, Texas, filed a lawsuit today in Miami federal court, calling the disabled Triumph cruise ship "a floating hell."

"Plaintiff was forced to endure unbearable and horrendous odors on the filthy and disabled vessel, and wade through human feces in order to reach food lines where the wait was counted in hours, only to receive rations of spoiled food," according to the lawsuit, obtained by ABCNews.com. "Plaintiff was forced to subsist for days in a floating toilet, a floating Petri dish, a floating hell."

Click Here for Photos of the Stranded Ship at Sea

The filing also said that during the "horrifying and excruciating tow back to the United States," the ship tilted several times "causing human waste to spill out of non-functioning toilets, flood across the vessel's floors and halls, and drip down the vessel's walls."

Terry's attorney Brent Allison told ABCNews.com that Terry knew she wanted to sue before she even got off the boat. When she was able to reach her husband, she told her husband and he contacted the attorneys.

Allison said Terry is thankful to be home with her husband, but is not feeling well and is going to a doctor.

Carnival's Triumph Passengers: 'We Were Homeless' Watch Video

Girl Disembarks Cruise Ship, Kisses the Ground Watch Video

Carnival Cruise Ship Passengers Line Up for Food Watch Video

"She's nauseated and actually has a fever," Allison said.

Terry is suing for breach of maritime contract, negligence, negligent misrepresentation and fraud as a result of the "unseaworthy, unsafe, unsanitary, and generally despicable conditions" on the crippled cruise ship.

"Plaintiff feared for her life and safety, under constant threat of contracting serious illness by the raw sewage filling the vessel, and suffering actual or some bodily injury," the lawsuit says.

Despite having their feet back on solid ground and making their way home, many passengers from the cruise ship are still fuming over their five days of squalor on the stricken ship and the cruise ship company is likely to be hit with a wave of lawsuits.

"I think people are going to file suits and rightly so," maritime trial attorney John Hickey told ABCNews.com. "I think, frankly, that the conduct of Carnival has been outrageous from the get-go."

Hickey, a Miami-based attorney, said his firm has already received "quite a few" inquiries from passengers who just got off the ship early this morning.

"What you have here is a) negligence on the part of Carnival and b) you have them, the passengers, being exposed to the risk of actual physical injury," Hickey said.

The attorney said that whether passengers can recover monetary compensation will depend on maritime law and the 15-pages of legal "gobbledygook," as Hickey described it, that passengers signed before boarding, but "nobody really agrees to."

One of the ticket conditions is that class action lawsuits are not allowed, but Hickey said there is a possibility that could be voided when all the conditions of the situation are taken into account.

One of the passengers already thinking about legal action is Tammy Hilley, a mother of two, who was on a girl's getaway with her two friends when a fire in the ship's engine room disabled the vessel's propulsion system and knocked out most of its power.

"I think that's a direction that our families will talk about, consider and see what's right for us," Hilley told "Good Morning America" when asked if she would be seeking legal action.

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